发明名称 |
PYRIMIDINE DERIVATIVES, A PROCESS FOR PREPARING THEM AND A PHARMACEUTICAL COMPOSITION CONTAINING THEM |
摘要 |
New 4-anilinopyrimidine derivatives of formula (I): <IMAGE> (I) (wherein: R1 and R2 are the same or different and each represents a C1-C6 alkyl group or R1 and R2 together represent a C3-C5 alkylene group; R3 represents a hydrogen atom or a C1-C6 alkyl group; n is 0, 1 or 2; and R4 represents a C1-C6 alkyl group, a C1-C6 alkoxy group, a C1-C6 haloalkyl group, a halogen atom, a nitro group, a C1-C6 alkanesulphonyl group, a cyano group, a carboxy group or a C2-C7 alkoxycarbonyl group and, when n is 2, the two groups represented by R4 may be the same or different or they may together represent a methylenedioxy group) and pharmaceutically acceptable acid addition salts thereof have been found to have strong antidepressant activity, with low toxicity and very few side-effects. The compounds may be formulated in conventional pharmaceutical compositions for administration by various routes and may be prepared by reacting a 4-halopyrimidine with aniline or an aniline derivative. |
申请公布号 |
DE3263653(D1) |
申请公布日期 |
1985.06.13 |
申请号 |
DE19823263653 |
申请日期 |
1982.06.03 |
申请人 |
SANKYO COMPANY LIMITED;UBE INDUSTRIES, LTD. |
发明人 |
KAMIOKA, TOSHIHARU BIOLOGICAL RESEARCH LAB.;NAKAYAMA, ISAO BIOLOGICAL RESEARCH LAB.;HONDA, TAKEO;FUJII, KATSUTOSHI;KOBAYASHI, TAKASHI;OBATA, TOKIO KOJIMA MIKIO;AKIYOSHI, YUJI |
分类号 |
A61K31/505;A61K31/517;A61P25/24;A61P25/26;C07D239/42;C07D239/70;C07D239/94;(IPC1-7):C07D239/42 |
主分类号 |
A61K31/505 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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