发明名称 |
N-BENZYLOXYCARBONYL-L-ASPARTIC ACID |
摘要 |
N-Benzyloxycarbonyl-L-aspartic acid (Z-Asp) is synthesized by adding benzyl chloroformate to a solution of L-aspartic acid and sodium hydroxide at temperatures from about 5 DEG -55 DEG C. and over a wide pH range of about 9.2 to 13.8 in the presence of a surfactant and/or a buffer and then acidifying the reaction mixture. Carrying out the reaction in the presence of a surfactant reduces cycle time, while maintaining a high yield with low by-product content. The buffer prevents wide fluctuations in pH and minimizes localized reaction. These conditions are desirable when the reaction rate has been increased by addition of a surfactant or an increase in temperature of the reaction mixture. |
申请公布号 |
GB2149396(A) |
申请公布日期 |
1985.06.12 |
申请号 |
GB19840021155 |
申请日期 |
1984.08.21 |
申请人 |
* HATCO CHEMICAL CORPORATION |
发明人 |
CLAY TZU-CHIM * CHEN;K MING * WAN;MARY SHUI-CHU * CHEN |
分类号 |
C07C271/22;A23L27/30;C07C67/00;C07C239/00;C07K5/075 |
主分类号 |
C07C271/22 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|