| 摘要 |
NEW MATERIAL:A compound expressed by formula I (R is lower alkyl). EXAMPLE:Methyl 2-acetoxy-3-chloro-(4-methoxyphenyl)propionate. USE:A synthetic intermediate for medicines. For example, useful as a synthetic intermediate for 2-(4-methoxyphenyl)-3-acetoxy-5-(2-dimethylaminoethyl)-2,3-dihydro-ben zothiazepin-4(5H)-one having coronary vasodilator action. PREPARATION:An alkyl p-methoxycinnamate expressed by formula II is reacted with chromyl chloride expressed by the formula CrO2Cl2 in an organic solvent under cooling or refluxing under heating for 30min-24hr to form a compound expressed by formula III, which is then acetylated with an aceylating agent, e.g. an acetyl halide or acetic anhydride, to afford the aimed compound expressed by formula I .
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