Process for preparing salicylamide compounds.

摘要

The invention relates to a process for preparing with high yield and purity salicylamide compounds of the formula <CHEM> where X is a benzene ring or a heterocyclic aromatic group, R1 is a hydrogen atom or a substituent group which is -COCnH2n + 1 or -CnH2n + 1 where n is an integer of from 1 to 15, and R2 is a hydrogen atom or a substituent group which is CN, NO2, F, Cl, Br, I, CF3, CCl3, CBr3, Cl3, COCnH2n + 1 or CnH2n + 1. The process involves a first step of reacting a phenyl salicylate, optionally substituted by the group R1, with the amine NH2-X-R2. Subsequent steps involves addition of solvent and Lowry-Bronsted acid with a refluxing stage prior to precipitation and recovery of the salicylamide compound.