| 摘要 |
Compounds of general formula (I> <IMAGE> (wherein R1 and R2 are be the same or different and each represent hydrogen, C1-5 alkyl, C2-5 alkenyl, aralkyl or C3-7 cycloalkyl, or (together with the nitrogen atom to which they are attached) form a 5 to 10 membered ring, which may be saturated or contain at least one double bond; and R3 denotes C1-4 alkyl or C2-4 hydroxyalkyl) are prepared by a new process which comprises reducing an aryloxyalkylamine of general formula (II), <IMAGE> reacting the dihydroaryloxyalkylamine of general formula (III) thus obtained, <IMAGE> with N-cyanoiminodithiocarbamic acid dimethyl ester, reacting the isothiocarbamide of general formula (IV) thus obtained, <IMAGE> with a substituted hydrazine of general formula (V), R3-NH-NH2 (V> and, if desired, converting the dihydroaryloxyalkylamino-1,2,4-triazole of general formula (I) thus obtained into a pharmaceutically acceptable salt. The compounds of general formula (I) are potent H2-antagonists and inhibit the secretion of gastric acid when this is stimulated via histamine receptors. |
