| 摘要 |
NEW MATERIAL:The compound of formula I [R1 is pGlu, X-R2-CO-(X is H, carboxyl or amino; R2 is lower alkylene), etc.; A is Asp or single bond; B is Tyr (SO3H) or Phe(NHSO3H); C is Met, Leu, etc.; D is Gly or D-amino acid; E is met, Leu, etc.; Y is NH2, Asp-NH2, etc.]. USE:A cholecyst contracting agent, pancreatic juice secretion promoting agent, sedative, analgesic, reagent for clinical examination, etc. PREPARATION:The peptide of formula II, etc. is produced e.g. by the stepwise process to condense amino acids one by one to the terminal amino acid. If necessary after protecting the active group such as amino group, the peptide is subjected to the sulfating reaction to introduce the sulfuric acid ester group of formula III to the Tyr residue and to obtain the objective compound of formula I . |
