| 摘要 |
PURPOSE:A carcinostatic agent containing a neocarzinostatin derivative having low toxicity, being accumulated specifically in lymphocyte. CONSTITUTION:A carcinostatic agent containing a compound shown by the formula (ring N is neocarzinostatin residue; R1+R2 is residue of styrene-maleic acid copolymer having 2,500-80,000mol.wt) as an active ingredient. Administration in tissue of affected part such as primary site of cancer, site from which cancer is extracted after operation, etc., intracutaneous, hypodermic, intramuscular, intravenous, and oral medication, etc., application to the affected part, and administration of external use such as suppository may be used as the administration. A dose is 0.1-10mg/kg/time/day, preferably once-twice per week or daily administration. The compound shown by the formula as the active ingredient is obtained by reacting neocarzinostatin with a styrene-maleic acid copolymer containing at least one maleic anhydride residue in the molecule in neutrality or in weak basicity at 0-40 deg.C.
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