发明名称 |
N-substituted [bis(hydroxymethyl)-methyl]-isoquinoline derivatives, process for preparing them and pharmaceutical compositions containing them. |
摘要 |
The subject matter of the application are new N-substituted Äbis(hydroxymethyl)-methylÜ-isoquinoline derivatives of the formula (I) <CHEM> wherein R<1> and R<2> represent hydroxyl or alkoxy having from 1 to 6 carbon atoms, the dotted line is an optional second bond in the 1,2-position, R<3> is alkyl having from 1 to 6 carbon atoms or aralkyl containing from 1 to 4 carbon atoms in the alkyl moiety,or - if there is a single bond in the 1,2-position - further may represent a group of the formula <CHEM> in which either X is oxygen and R<4> is alkyl having from 1 to 5 carbon atoms, alkoxy having from 1 to 4 carbon atoms, hydroxyl or phenyl, optionally substituted, preferably by one or more alkyl having from 1 to 4 carbon atoms, alkoxy having from 1 to 4 carbon atoms, halogen and/or nitro, or is an -NH2, -NH-C1-4-alkyl, -NH-C3-6-cycloalkyl, -NH-phenyl or -NH-C1-4-alkyl-phenyl group; or X is sulfur and R<4> is an -NH2, -NH-C1-4-alkyl, -NH-C3-6-cycloalkyl, -NH-phenyl or -NH-C1-4-alkyl-phenyl group; and further R<5> and R<4> independently stand for hydrogen, alkyl having from 1 to 4 carbon atoms or phenyl, with the proviso that at least one of them is other than phenyl, and salts thereof as well as a process for preparing these compounds and pharmaceutical compounds containing them.
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申请公布号 |
EP0142740(A1) |
申请公布日期 |
1985.05.29 |
申请号 |
EP19840112855 |
申请日期 |
1984.10.25 |
申请人 |
RICHTER GEDEON VEGYESZETI GYAR R.T. |
发明人 |
BERNATH, GABOR, DR. DIPL.-CHEM.;KOBOR, JENO, DR.;FULOP, FERENC, DR. DIPL.-CHEM.;PERJESI, PAL, DR. DIPL.-PHARM.;EZER, ELEMER, DIPL.-CHEM.;HAJOS, GYORGY, DR. DIPL.-PHARM.;PALOSI, EVA, DR.;DENES, LASZLO, DR. DIPL.-PHARM.;SZPORNY, LASZLO, DR. |
分类号 |
A61K31/47;A61K31/472;A61P1/04;A61P25/04;A61P29/00;A61P37/06;C07D217/16;(IPC1-7):C07D217/16 |
主分类号 |
A61K31/47 |
代理机构 |
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