发明名称 1-N-ALKYLCARBOXY-BENZOFUSED LACTAMS USEFUL AS ANTIHYPERTENSIVE AGENTS
摘要 Compounds of the formula: <CHEM> wherein: R<1> is, e.g., hydrogen or alkyl of from 1 to 12 carbon atoms; R<2> and R<4> are independently, e.g., hydroxy or loweralkoxy; m is 1-4; R<3> is <CHEM> where n is 2-5; provided that where n = 3 or 4, the carbon chain may be unsaturated between carbons 2-3 for n = 3, and between carbons 2-3 or 3-4 or both for n = 4; the R<a>'s are independently, e.g., hydrogen or hydroxy; and the R<b>'s are independently hydrogen or loweralkyl; R<5> is hydrogen; halo; hydroxy; loweralkyl; loweralkoxy; amino; or mono- or diloweralkylamino; and a pharmaceutically acceptable salt thereof. Those compounds are inhibotors of angiotensin I converting enzyme useful as antihypertensive agents.
申请公布号 ZA8307271(B) 申请公布日期 1985.05.29
申请号 ZA19830007271 申请日期 1983.09.29
申请人 MERCK & CO. INC. 发明人 WILLIAM H. PARSONS
分类号 A61K31/395;A61K31/47;A61K31/55;A61K38/00;A61P9/12;C07D215/38;C07D223/16;C07D225/04;C07D225/06;C07D227/10;C07K5/02 主分类号 A61K31/395
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