SUBSTITUTED BETA-CARBOLINES,PROCESS FOR THE PREPARATION THEREOF,AND USE THEREOF AS MEDICINAL AGENTS

摘要

Novel substituted beta -carboline derivatives of Formula I (I) wherein R3 is an oxadiazolyl residue of the formula wherein R5 stands for lower alkyl of up to 3 carbon atoms or an ester with R6 being hydrogen or lower alkyl of up to 3 carbon atoms, R4 is hydrogen, lower alkyl of up to 3 carbon atoms, or CH2OR9 wherein R9 is lower alkyl of up to 3 carbon atoms, RA is phenyl or a hydrocarbon residue containing 2-10 carbon atoms which can be cyclic or acyclic, saturated or unsaturated, branched or unbranched, and which can optionally be substituted by oxo, formyl OH, O-alkyl of up to 3 carbon atoms or phenyl, and wherein, in a cyclic hydrocarbon residue, a CH2-group can be replaced by oxygen, exhibit an effect on the central nervous system and thus are suitable as psychopharmaceuticals.