发明名称 |
Synthesis of thiophene-containing prostaglandin endoperoxide analogs |
摘要 |
New organopalladium reactions involving the addition of thienylpalladium compounds to strained bicyclic alkenes, and subsequent chain extension reactions employing the chemistry of organopalladium compounds are disclosed. By these techniques a large number of bicyclic prostaglandin analogs are prepared, which are useful as inhibitors of arachidonic acid induced blood platelet aggregation, and are specific inhibitors of thromboxane synthetase.
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申请公布号 |
US4520207(A) |
申请公布日期 |
1985.05.28 |
申请号 |
US19820423789 |
申请日期 |
1982.09.27 |
申请人 |
IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. |
发明人 |
LAROCK, RICHARD C. |
分类号 |
C07C405/00;C07D333/24;C07F1/02;C07F3/14;C07F15/00;(IPC1-7):C07D333/24 |
主分类号 |
C07C405/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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