| 摘要 |
7 beta -Acylamino-3-azido-3-cephem-4-carboxylic acid esters are obtained from the corresponding 3-halo or 3-sulfonyloxy-3-cephem esters and an alkali metal azide. The 3-azido compounds as the free acids or salts are antibacterial agents while in esterified form react with alcohols and phenols to provide 2-alkoxy (or 2-phenoxy)-3-amino-3-cephem esters and isomeric ring explained 4,7-bicyclo beta -lactam compounds, namely [2R-(2 alpha ,7 alpha ,8 alpha )-4-alkoxy (or 4-phenoxy)-9-oxo-8-acylamino-6-thia-1,3-diazabicyclo[5.2.0]non-3-ene-2-carboxyli c acids and esters and the corresponding 3-alkoxy (or 3-phenoxy) 1,4-diazabicyclo[5.2.0]non-3-ene-2-carboxylic acids and esters. The products obtained from the azide possess antibacterial properties. |
