| 摘要 |
The present invention pertains to uses for diphenylhalonium ion having formula (I), to elicit sodium nitroprusside-like effects in vivo, and to enhance cardiac contractility. Heretofore, sodium nitroprusside, which must be administered intravenously, and cardiac glycosides, which display a weak inotropic effect, were widely used to treat chronic heart failure. With the present invention, chronic heart failure can be treated, via routes of administration other than intravenous injection, by elicitation of sodium nitroprusside-like effects, including enhancement of cGMP levels, in conjunction with a significant inotropic effect. |
