发明名称 Omega-cycloalkyl prostaglandins.
摘要 <p>This invention encompasses prostaglandins of the formula I</p><p>&lt;Chemistry id="chema01" num="0001"&gt;&lt;Image id="ia01" he="26" wi="83" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /&gt;&lt;/Chemistry&gt;wherein X represents cis or trans -CH=CH-, -C≡-, methylene or ethylene; &lt;UnorderedLists id="ula01" listStyle="none"&gt;&lt;ListItem&gt;R, represents a cycloalkyl group of the formula &lt;Chemistry id="chema02" num="0002"&gt;&lt;Image id="ia02" he="17" wi="29" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /&gt;&lt;/Chemistry&gt;where m is 1 to 3 inclusive&lt;/ListItem&gt;&lt;ListItem&gt;R&lt;Sub&gt;2&lt;/Sub&gt; represents hydrogen or lower alkyl with the proviso that the sum of the carbon atoms in X and R, is 7 or less.&lt;/ListItem&gt;&lt;ListItem&gt;R' represents lower alkyl containing 1 to 6 carbon atoms, vinyl or ethynyl;&lt;/ListItem&gt;&lt;ListItem&gt;wherein R''' represents hydroxymethyl, hydroxyacetyl or -CO&lt;Sub&gt;2&lt;/Sub&gt; R''''&lt;/ListItem&gt;&lt;ListItem&gt;wherein R"" represents hydrogen or lower alkyl containing 1 to 6 carbon atoms and the wavy line represents optional R or S stereochemistry.&lt;/ListItem&gt;&lt;/UnorderedLists&gt;</p>
申请公布号 EP0142158(A2) 申请公布日期 1985.05.22
申请号 EP19840113676 申请日期 1984.11.13
申请人 G.D. SEARLE & CO. 发明人 COLLINS, PAUL WADDELL;GASIECKI, ALAN FRANK
分类号 A61K31/557;A61K31/5575;A61P1/04;A61P43/00;C07C67/00;C07C401/00;C07C405/00;(IPC1-7):C07C177/00 主分类号 A61K31/557
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