Process for preparing substituted pyrimidinones and intermediates therefor.

摘要

Compounds of the formula: <CHEM> wherein R is hydroxy, mercapto or methylthio and het is an optionally substituted acid stable, 5- or 6-membered heteroaryl ring having at least one nitrogen ring member are described. These are prepared by reacting a 5H-pyrimidine with a heteroarylaldehyde. These compounds are useful in that they may be reduced to a corresponding heteroarylmethyl pyrimidine and subsequently elaborated to form a histamine antagonist.