Process for the preparation of an inclusion complex of N-(1--phenylethyl)-3,3-diphenylpropylamine and the hydrochloride thereof respectively with cyclodextrin

摘要

PCT No. PCT/HU82/00024 Sec. 371 Date Dec. 22, 1982 Sec. 102(e) Date Dec. 22, 1982 PCT Filed May 12, 1982 PCT Pub. No. WO82/04052 PCT Pub. Date Nov. 25, 1982.An inclusion complex is disclosed of N-(1-phenylethyl)-3, 3-diphenyl-propylamine or its hydrochloride complexed with a cyclodextrin as well as a process for the preparation thereof and pharmaceutical compositions containing same. The new inclusion complexes have coronary dilatory activity and have greater water soluble than simple N-(1-phenylethyl)-3, 3-diphenyl-propyl amine or the hydrochloride thereof.