| 摘要 |
This invention encompasses prostaglandins of the formula I <IMAGE> I wherein R''' represents hydroxymethyl, hydroxyacetyl or -CO2R'''' wherein R'''' represents hydrogen or lower alkyl containing 1 to 6 carbon atoms; R' represents lower alkyl containing 1 to 6 carbon atoms, vinyl or ethynyl; R'' represents cycloalkyl containing 3 to 5 carbon atoms; and the wavy line represents optional R,S stereochemistry. These compounds are potent antisecretory compounds and cytoprotective agents with reduced diarrhea side effects. |
