METHOD OF 1,5,10-TRIAZADECANES PRODUCTION SUBSTITUTED IN 1%POSITION BY MEANS OF (OMEGA-QUANIDINELAKANOYL) AMINO ACID'S RESIDUE

摘要

This invention relates to a novel spergualin-related compound and a process for the production thereof. The novel compound, which has a high antitumor activity, is represented by the general formula (I) wherein R1 represents a hydrogen atom, hydroxyl group, or an aliphatic acyloxy group having 1 to 10 carbon atoms, R2 represents an amino acid residue (except for the residue of alpha -hydroxyglycine) formed by removing one hydrogen atom and hydroxyl group from respectively the alpha - or omega -amino group and the alpha -carboxyl group of an alpha - or omega -amino acid, said amino acid residue forming acid amide linkages with the adjacent carbonyl group and amino group, and m is an integer of 4 to 6.