DERIVATIVE OF N-ACETILCYSTEINE HAVING THERAPEUTICAL ACTIVITY, PROCESS FOR ITS PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS

摘要

The thioester of N-acetylcysteine with p-isobutylphenylpropionic acid simultaneously shows anti-inflammatory and mucolithic activities. It is prepared by reacting a reactive derivative of p-isobutylphenylpropionic acid and N-acetylcysteine at low temperature and in a polar solvent. The salts with organic and inorganic bases, with basic aminoacids and with basic antibiotics having macromolecular structure, are stable and generally water soluble, whereby the active principle of the invention can be formulated for oral, parenteral, rectal and topical administration.