发明名称 |
Deletion mutant of a herpesvirus and vaccine containing said virus. |
摘要 |
<p>The invention relates to live deletion mutants of a herpesvirus, especially of Pseudorabies virus. The genomes of the mutants differ from the genomes of the parent strain by the presence of one or more deletions selected from a deletion in the inverted repeats, a deletion in the unique sequence, and a delection in the thymidine kinase gene.</p><p>The new deletion mutants are avirulent, do not induce latent infections, are stable and possess good immunogenic properties.</p><p>The invention also relates to vaccines containing the new mutant strains.</p> |
申请公布号 |
EP0141458(A1) |
申请公布日期 |
1985.05.15 |
申请号 |
EP19840201474 |
申请日期 |
1984.10.12 |
申请人 |
CENTRAAL DIERGENEESKUNDIG INSTITUUT |
发明人 |
BERNS, ANTONIUS JOZEF MARIA;GIELKENS, ARNOLD LEONARD JOZEF |
分类号 |
C12N15/09;A61K39/00;A61K39/245;C07K14/03;C12N7/00;C12N7/04;C12N15/00;C12R1/91 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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