摘要 |
Compounds of formula (I): <IMAGE> (I) or a pharmaceutically acceptable salt thereof, in which R1 is hydrogen, halogen, or trifluoromethyl, R2 is hydrogen or halogen, R3 is hydroxyl, C1-6 alkoxy or <IMAGE> where R8 and R9 are each hydrogen or C1-6 alkyl; R4 is hydrogen or C1-6 alkyl; R5 is hydrogen, C1-6 alkyl, C1-6 alkyl optionally substituted by hydroxy; cyano, C1-6 alkenyl or C1-6 alkynyl optionally substituted by carboxy or esters and amides thereof, phenyl, C1-6 alkyl phenyl or a group <IMAGE> wherein R12 and R13 are each hydrogen or C1-6 alkyl or together, along with the nitrogen to which they are attached, form a 5- or 6-membered ring and m is 1 or 2; R6 is hydrogen or methyl: R7 is -O(CH2)aCO2H, -O(CH2)bM, -CO2H; or amide thereof in which a is an integer from 1 to 6, b is an integer from 2 to 7, and M is hydroxy, C1-6 alkoxy or <IMAGE> in which R10 and R11 are each hydrogen or C1-6 alkyl or <IMAGE> together form a five or six membered ring; and n is 1 or 2; with the proviso that when n is 2 and R1, R2, R4 and R6 are each hydrogen and R3 is hydroxyl, R5 is not hydroxymethyl or 1-hydroxy ethyl when R7 is CONH2; processes for preparing such compounds and their use in medicine. |