ORGANOTIN COMPOUND OR AMINE SALT THEREOF

摘要

NEW MATERIAL:A compound of formula I [R<1> is alkyl or aryl; B is base residue (having a protecting group); Y is R<2> or formula II (R<2> and R<3> are protecting group; R<4> is protecting group, deoxynucleoside residue or deoxynucleotide residue)] and an amine salt thereof. EXAMPLE:5'-O-Triethylstannyl-3'-O-tert-butyldimethylsilylthymidine. USE:An intermediate for producing oligonucleotides. PREPARATION:An organotin amide compound of formula III (R<5> and R<6> are H, alkyl or aryl) is reacted with a deoxynucleoside of formula IV or a deoxynucleotide of formula V to afford the aimed compound of formula I .