| 摘要 |
<p>NEW MATERIAL:A compound of formula I [R<1> is -(CH2)mCOOH (m is 0 or an integer 1-3), -(CH2)mOH, -(CH2)mNHR<2> (R<2> is H or acyl), amino lower alkyl or sulfo, etc.]. EXAMPLE:(z)-7-{alpha-( 2-Amino-4-thiazolyl )-alpha-[( 2-amino-4-thiazolyl )methoxyimino] acetamido}-3-( 3-carboxylatomethyl-1-pyridiniomethyl )-3-cephem-4-carboxylate monosodium salt. USE:An antimicrobial agent capable of exhibiting improved activity particularly against Gram-positive bacteria. PREPARATION:A substituted oximinothiazolylacetic acid derivative of formula II(R<4> and R<5> are H or a protecting group of the amino group) is reacted with a 7-amino-3-cephem derivative of formula III in a solvent under cooling - at room temperature, and if necessary the protecting group is removed to afford the aimed compound of formula I .</p> |
