Cells and their use in methods for producing product compounds.

摘要

Cells which are: 1) capable of converting a raw material to a product compound not produced in the glycolytic pathway via a first bioconversion pathway which does not produce a tricarboxylic acid cycle (TAC) intermediate; 2) capable of producing a net increase in a TAC intermediate from a first carbon source via a second bioconversion pathway inhibitable by an inhibiting compound produced in the glycolytic pathway; and 3) incapable of producing a net increase in a TAC intermediate other than via the second bioconversion pathway. The cells are used in a method to produce the product compound.