摘要 |
<p>This invention deals with the compounds of the formulae: <CHEM> wherein Z is thio, sulfinyl, or sulfonyl; R<1> and R<2> are independently hydrogen, halogen, amino, C1 to C4 alkyl, C1 to C4 alkylthio, C1 to C4 alkoxy, thiol, C1 to C4 alkylsulfinyl, C1 to C4 alkylsulfonyl, trifluoromethyl, trifluoromethylthio, cyano, nitro, aralkyl, hydroxyalkyl, C1 to C4 alkylamino, dialkylamino wherein each alkyl group has 1 to 4 carbons, or R<1> and R<2> are joined together to form a polymethylene chain of 3 or 4 carbon atoms, with or without a hydroxy or keto functionality; X is O, N-R<3>, wherein R<3> is hydrogen, C1 to C4 alkyl, aryl, hydroxy, C1 to C4 alkoxy, C1 to C5 acyloxy, amino, C1 to C4 alkylamino or dialkylamino wherein each alkyl group has 1 to 4 carbons; or a group of the formula: <CHEM> wherein each Y is independently O or S or NR<6> wherein R<6> is H, C1 to C4 alkyl, lower alkanoyl, benzoyl, trifluoroacetyl or CN; and R<4> and R<5> are each independently hydrogen or C1 to C4 alkyl and the broken line between R<4> and R<5> represents an optional bond when R<4> and R<5> are not hydrogen; and the pharmaceutically acceptable salts thereof. These compounds are useful for antagonizing the activity of prostaglandins in a mammal.</p> |