摘要 |
<p>Trans-(+/-)-2-Amino (or substituted amino)-4-(permissibly-substituted)-6-C1-C3 alkyl (or allyl)-5,5a,-6,7,8,9,9a,10-octahydropyrimido[4,5-g]quinolines, the corresponding trans-(-) and trans-(+)-stereoisomers and salts thereof, useful in treating Parkinson's Syndrome, sexual dysfunction, depression, hypertension, and prolactin related diseases, and intermediates useful for the synthesis thereof, are disclosed. The products are prepared by condensing an appropriate ketone with the appropriately substituted guanidine.</p> |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
NICHOLS, CYNTHIA LYNN;KORNFELD, EDMUND CARL;FOREMAN, MARK MORTENSEN;SCHAUS, JOHN MEHNERT;HUSER, DIANE LYNN;BOOHER, RICHARD NOLAN;WONG, DAVID TAIWAI |