| 摘要 |
<p>A system, method and device for continuously fractionating blood in situ. The fractionating device (25) is connected in a closed loop to the donor (30) and includes interleaved blood plates (55) and blood fraction plates (50) separated by a semipermeable membrane (75). Grooves (95) in the plates direct blood flow and blood fraction collection. Uniform distribution among the plates (50, 55) and intraplate (60) is obtained by manifolds (110). A device (25) for continuously producing blood fraction, comprises a stack (45) of at least two plates (50, 55) having at least one surface (102) with a blood flow channel (100) therein separated by a semipermeable membrane (75) selectively permeable to the blood fraction, an inlet (26) for conducting blood to each blood flow channel (100) and an outlet (36) for conducting blood therefrom to establish a longitudinally extending blood flow path, each blood flow channel (100) having a distribution portion (110) for uniformly distributing blood transversely of the blood flow path and a transfer portion (160) extending longitudinally thereof, each collection channel (90) being substantially in registry with said transfer portion (160) of said facing blood flow channel (100) for receiving the blood fraction passing through said membrane (75), and a fraction outlet (98) for conducting the blood fraction from each collection channel (90), whereby the blood fraction continuously transfer from blood passing through said transfer portion (160) of each blood flow channel (100) through the membrane (75) to the adjacent collection channel (90) to said fraction outlet (98).</p> |
