| 摘要 |
<p>Bicyclo-diaza-heterocycles of formula (I) and their salts are new (B is methylene, ethylene or vinylene. R1 is H or alkyl (opt. substd. by aryl; amino (itself opt. substd. by 1 or 2 alkyl); acylamino; phthalimido; alkoxy-, aryloxy- or aralkoxy-carbonylamino; alkyl-, aryl- or aralkyl- aminocarbonylamino; or alkyl- or aryl-sulphonylamino). R2 is carboxy, alkoxycarbonyl, aralkoxycarbonyl, -PO(OH)2 or -CONR6R7. R3 is carboxy, alkoxycarbonyl or aralkoxycarbonyl. R4 and R5 are both H or together form oxo. R6 and R7 are H, alkyl, aralkyl or together complete a satd., 5 or 6 membered heterocycle, opt. contg. an additional N, O or S atom. n is 0-2). (I) are antihypertensives (inhibitors of angistension-converting enzyme). They are formulated conventionally for oral or parenteral administration, pref. at daily doses of 1-50 mg per kg..</p> |
