POLYPEPTIDES FOR THE DETECTION AND CONTROL OF MAMMALIAN CELL GROWTH

摘要

Neoplastic and other diseases can be diagnosed by assaying a human test sample e.g. body fluid, tissue or cultured tumour explant cells, for structurally altered or abnormally expressed growth factor receptors or for the mRNA transcripts of genes which encode them. Antibodies capable of binding a predetermined amino acid sequence within the EGF receptor are also useful in diagnosis and therapy as are conjugates of an immunogenic polymer bound to a polypeptide fragment of EGF receptor. DNA and RNA encoding EGF receptor or fragments thereof are also described.