| 摘要 |
NEW MATERIAL:The compound of formula I (X<1> is halogen; R<1> is H or lower alkyl; R<2> is lower alkyl, acetyl, carbamoyl or cyano) and its salt. EXAMPLE:1-Cyclopropyl-6-fluoro-7-( 3-methyl-1-piperazinyl )-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid. USE:Animal and fish drug, food preservative, sterilizing agent for external use, and disinfectant. PREPARATION:The compound of formula I or its salt (e.g. salt with methanesulfonic acid) can be produced in high yield, by reacting the compound of formula II with the compound of formula III in a solvent such as dimethyl sulfoxide, etc. at 50-150 deg.C, preferably 80-120 deg.C. The compound of formula II used as a starting material can be obtained by using the compound of formula III as a raw material. |
