发明名称 |
N-NAPHTHOYLGLYCINE DERIVATIVES |
摘要 |
Herein disclosed are N-naphthoylglycine derivatives having aldose reductase inhibiting activity. The derivatives are useful for treating diabetic complications. The derivatives are of the formula <CHEM> (where R<1> is hydrogen lower alkyl, lower alkenyl or phenylmethyl, R<2> is hydrogen or lower alkyl and R<3>, R<4> and R<5> are hydrogen or specified substituents) and therapeutically acceptable salts of the compounds wherein R<2> is hydrogen. Certain intermediate aminoacids useful in the preparation of the above mentioned derivatives also have aldose reductive inhibiting effects. |
申请公布号 |
EP0059596(B1) |
申请公布日期 |
1985.04.24 |
申请号 |
EP19820300940 |
申请日期 |
1982.02.24 |
申请人 |
AYERST, MCKENNA AND HARRISON INC. |
发明人 |
SESTANJ, KAZIMIR;ABRAHAM, NEDUMPARAMBIL ABRAHAM;BELLINI, FRANCESCO;TREASURYWALA, ADI;HUMBER, LESLIE GEORGE |
分类号 |
C07C327/48;A61K31/165;C07C63/72;C07C65/24;C07C69/94;C07C233/12;C07C327/38 |
主分类号 |
C07C327/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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