| 摘要 |
<p>Certain 2-azacycloalkylthio-2-penem-3-carboxylic acid compounds are useful as antibacterials for treating mammals and have the formula
<Chemistry id="chema01" num="0001"><Image id="ia01" he="57" wi="82" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>or a pharmaceutically acceptable salt thereof, wherein:
<UnorderedLists id="ula01" listStyle="none"><ListItem>Ris
<Chemistry id="chema02" num="0002"><Image id="ia02" he="41" wi="41" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry></ListItem><ListItem>A is alkylene having 2-4 carbon atoms, alkylene having 2-4 carbon atoms wherein a carbon atom has an oxo substituent or alkylene having 2-4 carbon atoms wherein a methylene is replaced by oxygen, S(O)<Sub>m</Sub>, or N-R<Sub>3</Sub>;</ListItem><ListItem>B is carbonyl, thiocarbonyl, methylene or imine;</ListItem><ListItem>R is hydrogen or forms an ester group which is hydroyzed in vivo;</ListItem><ListItem>R<Sub>2</Sub> is hydrogen, formyl, alkylcarbonyl, N-alkylaminocarbonyl, N-alkylaminosulfonyl, aminosulfonyl, aminocarbonyl, alkoxycarbonyl having 2-5 carbon atoms, alkylsulfonyl, alkyl, or alkyl substituted by aminocarbonyl, alkyl-S(O)<Sub>m</Sub>-, hydroxyl, amino, alkylcarbonylamino, formamido or alkylsulfonylamino, wherein each alkyl has 1-4 carbon atoms;</ListItem><!-- EPO <DP n="2"> --><ListItem>R<Sub>3</Sub> is hydrogen, methyl, formyl, methylcarbonyl or methylsulfonyl;</ListItem><ListItem>alk is alkylene having 1-4 carbon atoms;</ListItem><ListItem>n is zero or one; and</ListItem><ListItem>m is zero, 1 or 2.</ListItem></UnorderedLists></p> |
