| 摘要 |
PURPOSE:To obtain an antigonadotropic hormone substance useful for treating menopausal disorder, and tumors promoting the multiplication by hormones, etc., by extracting a bulbil of a plant of the genus Humulus of the family Moraceae with an alkaline solution. CONSTITUTION:A bulbil of a plant of the genus Humulus of the family Moraceae, e.g. Humulus lupulus (hop) or Humulus scandens Merrill, is extracted with an alkaline solution to give an antigonadotropic hormone substance. 1-5% aqueous ammonia, aqueous solution of sodium hydrogencarbonate, 0.001-0.01 N aqueous solution of NaOH, boric acid buffer solution of 8-11pH and tris buffer solution are preferred for the alkaline solution. The extraction temperature is preferably 3-20 deg.C. The above-mentioned substance is capable of antagonizing the biological action of gonadotropic hormone and reducing the sensitivity of the ovary to the gonadotropic hormone. Menopausal disorder, etc. can be treated by the antagonism of this substance to the gonadotropic hormone. |
