Packing materials for chromatographic use and a method for analysis of an enantiomer mixture using the same

摘要

A packing material for chromatographic use comprising an inorganic carrier having hydroxyl groups at the surface thereof having grafted thereon an organosilane derivative selected from the group consisting of a urea derivative obtained by reacting an optically active isocyanate with an aminoalkylsilane, an N-carbomoyl amino acid derivative obtained by reacting an optically active amino acid carbamoylated by isocyanate with an aminoalkylsilane and an O-carbamoyl hydroxy acid derivative obtained by reacting an optically active hydroxy acid carbamoylated by isocyanate with an aminoalkylsilane is disclosed. This packing material is useful as a packing material for liquid chromatography analysis which comprises separating and analyzing an enantiomer mixture of a compound having an -OH group, a -CONH- group, a -COO- group, an -NHCOO- group, an -NHCONH- group or bonded to an asymmetric carbon atom thereof.