N-DIHYDROTHIAZOLYL-3-QUINOLEINE CARBOXYAMIDE DERIVATIVES, THEIR SALTS, THEIR PREPARATION AND USE AS PHARMACEUTICAL PREPARATIONS, AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM

摘要

Novel N-(4,5-dihydro-thiazol-2-yl)-4-hydroxy-3-quinoline-carboxamides of the formula I wherein R is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms and R1 is selected from the group consisting of hydrogen, halogen, linear alkyl of 1 to 4 carbon atoms, branched alkyl of 3 to 5 carbon atoms, alkoxy of 1 to 4 carbon atoms, CF3-, CF3O-, CF3S- and CH3S- in the 6- or 7-position and their non-toxic, pharmaceutically acceptable acid addition salts having a strong anxiolytic activity and a remarkable affinity for benzodiapines receptors and their preparation.