| 摘要 |
Disclosed is a process for the total synthesis of 1-carbapenem antibiotics (I) from substituted 4-allylazetidinone (II) via central intermediate (III): <CHEM> wherein R is hydrogen, a pharmaceutically acceptable ester moiety or salt cation, or a readily removable blocking group, R<6>, R<7> and R<8> are, inter alia, independently selected from the group consisting of hydrogen, alkyl, alkenyl, aryl and aralkyl |
