摘要 |
<p>A process for the preparation of α-6-deoxy-tetracyclines by the stereoselective heterogeneous hydrogenation of a 6-demethyl-6-deoxy-6-methylene-tetracycline or an acid addition salt thereof, in the presence of a tertiary phosphine, or the simultaneous dehalogenation -and stereo-selective heterogeneous of an 11a-halo-6-demethyl-6-deoxy-6-methylene-tetracycline or an acid addition salt thereof, in the presence of a tertiary phosphine, characterised by the use of a rhodium salt catalyst, wherein the rhodium is bonded to an aminopolysiloxane, having the following formulae;
<TableDetails id="tabla01" num="0001"><Image id="ia01" he="23" wi="62" file="IMGA0001.TIF" imgContent="table" imgFormat="TIFF" inline="no" /></TableDetails>permitting easy recovery of the rhodium, by simple filtration.</p> |