Neocarzinostatin derivatives and a process for manufacturing the same.
摘要
<p>Neocarzinostatin derivatives. having excellent anticancer activity, have the formula (A)
(SMA)-(NCS)-(SMA) (A)
wherein (NCS) represents a divalent neocarzinostatin residue in which a hydrogen atom has been removed from each of the primary amino group of the alanine residue at the N-terminal of neocarzinostatin and of the primary amino group of the lysine residue at the 20th position from the N-terminal of neocarzinostatin and (SMA) represents a monovalent styrene-maleic acid copolymer residue having a weight-average molecular weight of from 800 to 2,500 and consisting of structural units of
(a) the styrene residue
<CHEM>
(b) the maleic acid residue
<CHEM>
and
(c) a residue having the following formula in which a hydroxyl group of one carboxylic group of a maleic acid residue has been removed to provide the link bonding the monovalent styrene-maleic acid copolymer residue to the necarzinostatin residue
<CHEM>
</p>
