| 摘要 |
NEW MATERIAL:The peptide of formula I (R is H or group of formula II; The amino acids are abbreviated according to the conventional sign specified by IUPAC or IUB or used widely in the relating fields). EXAMPLE:The peptide of formula III. USE:Drug having blood flow increasing action, insulin and prolactin-secretion increasing action, smooth muscle contracting action, etc. by the hormonic action of human gastrointestinal hormone (human PHI), and useful as a blood flow increasing agent, antidiabetic agent, hormonic preparation, prolactinoma diagnotic, immunity antigen for the preparation of human PHI antibody, etc. PREPARATION:The peptide of formula I can be produced by conventional peptide synthesis, e.g. stepwise condensation of the terminal amino acids one by one, or coupling of several fragments composed of the amino acids. |
