| 摘要 |
<p>A novel method of producing c cephalosporin compound of the formula <CHEM> wherein R<1> is a hydrogen atom or an acyl group; R is a hydrogen atom or an ester residue; the dotted line means a double bond in 2- or 3-position of the cephem ring; and R<4> is a nucleophilic compound residue, or a salt thereof, directly in one step from a compound of the formula <CHEM> wherein R<1>, R and the dotted line have the meanings defined above, or a salt thereof, by reacting in the presence of an organic solvent the compnind [II] or a salt thereof, a nucleophilic compound or a salt thereof, and (1) a trivalent or pentavalent cyclic phosphorus compound having a partial structure of the formula <CHEM> wherein W is an oxygen atom, a sulfur atom or NR<2>; W<1> is an oxygen atom, a sulfur atom or NR<3>; and R<2> and R<3> may be the same or different and each means a hydrogen atom or a hydrocarbon group, or a salt thereof, or (2) a reaction product of a compound having a partial structure of the formula <CHEM> wherein W and W<1> have the same meanings as defined above, or a salt thereof, with a phosphorus oxyhalide, trihalide or pentahalide.</p> |
