| 摘要 |
1,165,603. Diuretic &c. compositions. MERCK & CO. Inc. 24 Jan., 1967 [1 Feb., 1966], No. 3581/67. Heading A5B. [Also in Division C2] Pharmaceutical compositions having diuretic and saluretic activity comprise a compound of formula I in which each of R<SP>1</SP> and R<SP>2</SP> is hydrogen or alkyl or, taken together, R<SP>1</SP> and R<SP>2</SP> are joined to form an alkylene chain containing 1 to 3 carbon atoms between its points of attachment to the acylvinyl group, or a mononuclear cycloalkylidene-substituted alkylene chain containing 3 or 4 carbon atoms between its points of attachment to the acylvinyl group, the X substituents are similar or dissimilar and are halogen, alkyl, nitro or alkanamide or, taken together, two X substituents on adjacent carbon atoms of the benzene .ring are joined to form a bivalent hydrocarbon radical containing 3 or 4 carbon atoms between their points of attachment, Y is an alkylene or haloalkylene group having a maximum of 6 carbon atoms and containing 1 to 3 linear carbon atoms between the carbonyl group and the oxygen atom and n is 1, 2, 3 or 4, or a non-toxic, pharmacologically acceptable salt, ester or amide thereof, together with an inert pharmacologically acceptable diluent carrier or coating. The compositions may be administered orally or parenterally and may contain other known diuretics and saluretics or other therapeutic and/or nutritive agents. |
