OXACEPHALOSPORINS AND THEIR PREPARATION

摘要

New oxacephalosporins of the general formula (I) in which R1 is a protective radical and (a) R4 is a substituted 2-(2-aminothiazol-4-yl)-acetyl radical of which the amine group is protected, or an alpha -carboxyarylacetyl radical, and R'' is hydrogen or methoxy in the 7 alpha -position, or alternatively (b) R4 is a protective radical and R'' is hydrogen or methoxy in the 7 alpha -position or hydrogen in the 7 beta -position, in the form of a bicyclooct-2-ene or bicyclooct-3-ene or a 3-oxoethylidenebicyclooctane, are useful as intermediates for the preparation of pharmaceutically active oxacephalosporins.