PROCESS FOR THE PREPARATION OF ACYPEPTIDES

摘要

Acylpeptides of formula I [A= H-Ala-Gly-Cys-Cys, Ac-AlaGly-Cys-Cys, Ac-Cys-Cys; B= Lys,Lys(Ac); C= Asn, Ala, His; D= Phe, Cys; E= Phe, Trp; G= L-Ser, D-Ser; Ac-Acyl; a,b,c,f,g= 0,1 were prepared from somatostatins. The title compounds are useful as antidiabetics and/or for combating gastro-in-testinal bleeding. Daily dose for a warm- blooded, 70 kg animal is 0.1-120 mg.