| 摘要 |
NEW MATERIAL:The compound of formula I (R<1> is N-protecting group or substituent group; R<2> is H or OH-protecting group; R<3> is H, alkyl, aryl, aromatic heterocyclic group, halogen, acyl, substituted silyl, substituted hydroxy, substituted hydroxycarbonyl, substituted thio, substituted sulfinyl, substituted sulfonyl, cyano or nitro; A is -CidenticalC- or group of formula II). EXAMPLE:( 3S,4R )-1-[4-Methoxybenzyl]-4-phenylthioethynyl-3-[( 1R )-1-hydoxyethyl]-2-azetidinone. USE:Synthetic intermediate of a thienamycin compound (antibiotic substance). PREPARATION:The compound of formula I is produced by treating the compound of formula III (X is halogen) or the compound of formula IV with a base such as NaOH, KH, t-butyl lithium, etc. in a solvent such as benzene, toluene, etc. at -50-100 deg.C for 1min-24hr. |
