| 摘要 |
NEW MATERIAL:A fluorine-containing heterocyclic compound shown by the formula I (Rf is fluoroalkyl; R<1> and R<2> are alkyl; X is O or S; Y is F, fluoroalkyl or dialkylamino). EXAMPLE:A compound shown by the formula II. USE:An intermediate for a fluoro compound showing physiological activity such as antiviral activity, etc. PREPARATION:A fluoroacylurea shown by the formula III (Rf<1> and Rf<2> are preferably <=5C fluoroalkyl like Rf) or a fluoroacylthiourea is subjected to a ring formation reaction of dehydrofluorination by the action of especially a base (e.g., tertiary amine such as triethylamine, etc.) to give a compound shown by the formula I. Preferably the compound shown by the formula III is produced by reacting a fluoroacylcarboxylic acid fluoride shown by the formula IV with an N,N'-dialkylurea or N,N'-dialkylthiourea shown by the formula V under dehydrofluorination condition. |
