| 摘要 |
<p>2-Chloro-3-trifluoromethylbenzaldehyde and a process for preparing it characterised by (i) reacting 2-chloro-1-trifluoromethylbenzene with a C1-C4 alkyl lithium or phenyl lithium in an organic solvent at -60 DEG C or below (ii) reacting the product of step (i) with dimethylformamide at -60 DEG C or below and (iii) reacting the product of step (ii) with water. 2-Chloro-3-trifluoromethylbenzaldehyde is especially useful as an intermediate in the synthesis of 4-(2-chloro-3-trifluoromethylphenyl)-1,4-dihydropyridine calcium antagonists, especially 2-(2-aminoethoxymethyl)-4-(2-chloro-3-trifluoromethylphenyl)-3-ethoxyc arbonyl-5- methoxycarbonyl-6-methyl-1,4-dihydropyridine.</p> |
