发明名称 |
Alpha-alkyl polyolefinic carboxylic acids and derivatives thereof useful in the treatment of psoriasis and allergic responses |
摘要 |
Polyolefinic compounds represented by the general formula <IMAGE> in which R and R1 are each hydrogen or an alkyl group of from 1 to 5 carbon atoms; R2 is an alkyl group of from 1 to 5 carbon atoms; R3 is hydroxyl, alkoxy of from 1 to 5 carbon atoms, NH2, NHR2 or NR2R2 and Z is a cycloalkyl, cycloalkenyl or cycloalkdienyl group substituted with from 0 to 5 alkyl groups, a keto group or a hydroxyl group or a phenyl group substituted with from 0 to 4 hydroxy, alkoxy, alkyl or trifluoromethyl groups or halogen atoms or combinations thereof and the pharmaceutically-acceptable salts thereof. The foregoing compounds have been found to be effective in the treatment of psoriasis, inflammatory conditions and allergic responses.
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申请公布号 |
US4505930(A) |
申请公布日期 |
1985.03.19 |
申请号 |
US19830511822 |
申请日期 |
1983.07.08 |
申请人 |
USV PHARMACEUTICAL CORPORATION |
发明人 |
LOEV, BERNARD;CHAN, WAN-KIT;JONES, HOWARD |
分类号 |
A61K31/16;A61K31/20;A61K31/23;(IPC1-7):A61K31/16;A61L9/04 |
主分类号 |
A61K31/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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