| 摘要 |
Antidepressant benzazepines I [Y = H, F, Cl; X = H, Cl, Br; R = H, Br, Cl, iodo, C:CCH2R, C(:CHCH2R3)C:CCH2R3; R = H, alkyl, OH, amino; R3 = OH, amino; n = 0, 1 and their 1,2-dihydro derivatives were prepd. Thus, I (Y = F, X = Cl, R = C:CCH2NH2, n =0) (II) was prepd. from phthalimide III in 6 steps. II had an imipraminebinding ED50 of 20 mole in vitro.
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