23,23-DIFLUORO-1A,25-DIHYDROXY-VITAMIN D3

摘要

The invention provides a new derivative of vitamin D, 23,23-difluoro-1,25-dihydroxycholecalciferol. The compound is characterized by vitamin D-like activity as evidenced by its ability to increase intestinal calcium transport. It is further characterized by its resistance to hydroxylation at C-23, which is recognized as an essential metabolic step to the inactivation of vitamin D, and therefore should provide vitamin D-like activity of greater time duration.