PROCESS FOR PREPARING 5-(3-CHLORO-HYDROXYPHENYL)-3-HYDROXYMETHYL HYDANTOIN

摘要

5-(3-chloro-hydroxyphenyl)-3-hydroxymethyl hydantoin (I) used as an antibiotic agent against fungi, yeast, or bacteria is prepared from compound (III) by means of a reaction with formaldehyde. (III) is prepared from 5-(4-hydroxyphenyl) hydantoin (II) by means of a reaction with chlorine dissolved in methanol soln. for 1-2 hrs. at 30 (±5)≦̸C. Main reaction is conducted for 4 hrs. at 70-80≦̸C and a pH 7- 7.5 maintained by addition of aquueous ammonia.